[EU] Changes to Harmonised Classification of Chemicals 22 ATP of CLP

Commission Delegated Regulation amending Regulation (EC) No 1272/2008 of the European Parliament and of the Council as regards the harmonised classification and labelling of certain substances: 22 ATP to CLP.

The regulation added new harmonised classifications for 27 substances to Annex VI of CLP.

Several substances have been classified as CMR, which are used in cosmetics:

  • Silver (nano): [particle diameter > 1 nm ≤ 100 nm] H361f Repr 2, H373 STOT RE2 (nervous system)’
  • Silver Powder: [particle diameter > 100 nm < 1 mm] H361f Repr 2, H373 STOT RE2 (nervous system)’
  • Silver Massive: [particle diameter ≥ 1 mm] H361f Repr 2, H373 STOT RE2 (nervous system)’
  • Hexyl Salicylate (perfume ingredient) H361d Repr. 2
  • Copper [specific surface area > 0,67 mm2/mg] [CAS 7440-50-8] which covers the deleted entry for granulated copper [CAS 7440-50-8] (H400 Aquatic Acute 1, H410 Aquatic Chronic 1 )
    • Currently copper is listed as approved colourant (IV/132)
    • Copper (Nano) has been already banned aby cosmetic regulation and included in Annex II
  • α-methyl-1,3-benzodioxole-5-propionaldehyde [CAS 1205-17-0] (INCI: METHYLENEDIOXYPHENYL METHYLPROPANAL ) H317, Skin Sens. 1B
  • 2,4-dimethylcyclohex-3-ene-1-carbaldehyde [CAS 68039-49-6] INCI: 2,4-DIMETHYL-3-CYCLOHEXENE CARBOXALDEHYDE) H317, Skin Sens

Other substances classified as CMR cat. 1 that are permitted for use by professionals only:

  • acetone oxime [CAS 127-06-0], H350 Carc 1B
  • sodium 3-(allyloxy)- 2-hydroxypropanesulphonate [CAS 52556-42-0], H360F Repr.1B
  • benthiavalicarb-isopropyl (ISO) [CAS 177406 -68-7] H350 Carc.1B, H361 fd Repr.2

The regulation amended harmonised classifications for 16 existing substances in Annex VI of the CLP.

This includes but is not limited to:

  • N-hexane [CAS 110-54-3],
  • formaldehyde [CAS 110-54-3],
  • formic acid [CAS 64-18-6] – more stringent classification applied due to physical properties or human health effects
  • trimethyl borate [CAS 121-43-7] – tightened classification as CMR cat. 1
  • peracetic acid [CAS 79-21-0],
  • dibenzoyl peroxide [CAS 94-36-0],
  • dicamba (ISO) [CAS 1918-00-9] – expanded classification to include acute and/or chronic environmental toxicity

Stay Ahead of Regulatory Changes

The 22nd ATP to the CLP Regulation introduces significant updates that directly impact the cosmetics and chemicals industries, particularly regarding CMR classifications and environmental hazards. If your business handles any of the substances listed, now is the time to review formulations, update safety data sheets, and ensure compliance with the latest harmonised classifications.

Need help navigating these changes?
Reach out to our regulatory experts for tailored guidance and support in adapting to the new requirements.

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